In a year marked by volatility and innovation across tech, biotech, and finance sectors, the stock market has delivered some jaw-dropping performances. As of November 7, 2025, these 10 stocks have posted the highest year-to-date (YTD) gains, propelled by breakthroughs, strategic pivots, and investor fervor. From clinical triumphs to crypto bets, here’s a breakdown of the top performers and the catalysts behind their surges. Investors take note: while these gains are eye-popping, they often come with high risk in small-cap territory.
| Rank | Ticker | Company Name | YTD Gain | Key Driver |
|---|---|---|---|---|
| 1 | RGC | Regencell Bioscience Holdings Limited | 9,915% | Breakthrough clinical trial results for ADHD/ASD herbal treatments in Malaysia, plus CEO-led stock buyback boosting confidence |
| 2 | QMMM | QMMM Holdings Limited | 9,228% | Bold shift to cryptocurrency treasury and blockchain services, including a $100M Bitcoin/Ethereum/Solana strategy amid crypto hype |
| 3 | ABVX | ABIVAX Sociรฉtรฉ Anonyme | 1,338% | Game-changing Phase 3 success for obefazimod in treating ulcerative colitis, with 16.4% clinical remission rates sparking analyst upgrades |
| 4 | DFDV | DeFi Development Corp. | 1,223% | Explosive DeFi adoption and Solana token acquisitions, plus positive analyst ratings amid blockchain boom |
| 5 | SUPX | SuperX AI Technology Limited | 1,163% | AI infrastructure dominance with 800VDC power solutions for data centers and joint ventures fueling hyperscaler demand |
| 6 | TOI | The Oncology Institute, Inc. | 1,047% | Robust 21.8% revenue jump to $99.9M in Q3 2024, plus $16.5M private placement signaling expansion in value-based cancer care |
| 7 | NEGG | Newegg Commerce, Inc. | 1,047% | Heavy insider buying by Vladimir Galkin (over 3.6M shares) and sales events like FantasTech driving e-commerce momentum |
| 8 | ZEPP | Zepp Health Corporation | 950% | Amazfit smartwatch hits like Bip 6 and T-Rex 3 propelled 46% Q2 revenue growth, with Q3 guidance at 70-79% YoY |
| 9 | NVFY | Nova LifeStyle, Inc. | 700% | Gross margins expanded to 50% in Q2 on higher selling prices, narrowing losses amid furniture market recovery |
| 10 | PAPL | Pineapple Financial Inc. | 630% | $100M digital asset treasury launch and AI-enhanced mortgage platform partnerships targeting profitability by April 2025 |
These stocks highlight 2025’s theme: disruption pays off. Biotech and AI leads dominate, but DeFi and e-commerce plays show broad opportunity. Gains like RGC’s near-10,000% underscore the rewardsโand risksโof early-stage bets. Always diversify and consult advisors; past performance isn’t a guarantee.
